Since 2020, Factum Foundation has been collaborating with a team from the Physics, Materials Science and Engineering, and Art History and Art Departments at Case Western Reserve University in Cleveland, Ohio. The goal is to apply machine learning methods to surface profilometry images of paintings in order to attribute stylistic components of brushwork in some of the later paintings of El Greco. The aim is to explore differences between the hand of El Greco, those of his son Jorge Manuel and his workshop, and later conservation interventions.

The project comprises a close collaboration with the Fundación Casa Ducal de Medinaceli and the Hospital de Tavera in Toledo, and with The Auckland Project in Bishop Auckland.